What we for sure know, from numerous studies on the effects of orally ingested hyaluronic acid (also known as hyaluronan), is that it really has an impact on our body. The problem that occurs in this kind of administration is the very nature, and size of molecules. Experts who worked on the formulation of Bio Hyaluron ™ make this polymer down to a size that allows it facilitated absorption in the small intestine. The liquid formulation of the preparation allows better contact on surface of the epithelium in the small intestine, and therefore better utilization of Bio Hyaluron ™.
The practice in the pharmaceutical industry is to reduce manufacturing costs, so the hyaluronic acid is usuali obtained from poultry wastes (rooster combs). Hyaluronic acid, thus obtained, has a low purity. It is not insignificant fact that such raw materials, may contain impurities such as proteins, antibiotics, and there is a risk of contamination by viral particles. Also all these impurities are potential antigens in the human body that can trigger allergic reactions.
Technological process of manufacturing Bio Hyaluron™ is biofermentation from special strains of microorganisms. As the final result, we have a percentage of purity between 95% and 98%. Hyaluronic acid thus obtained has a minimum antigenic characteristics, because there is no possibility of contamination of the raw material as in the HA obtained from animal material. Because of these characteristics, Bio Hialuron™ is biocompatible, highly effective and safe to use.
Based on studies, hyaluronic acid, entered orally, mainly arrives in the skin and joints. The other positive effect on the body is that oraly enterd, hyaluronic acid stimulates our own cells to produce even more this precious molecule. Therefore, Bio Hyaluron™ is ideal supplement for healthy and beautiful skin, nails, hair, and healthy joints.
Hyaluronic acid –Structure and Synthesis
Hyaluronan or hyaluronic acid is a linear mucopolysaccharide, composed of a N-acetylglucosamine and D-glucuronic acidlinked 1,4 or 1,3β-glycosidic bond, and belongs to the group of glycosaminoglycans(GAGs), together with the chondroitin, heparan and similar molecules.
Hyaluronic acid –Representation in the body
Virtually all the cells of the human body have the ability to create hyaluronic acid. Hyaluronic acid is widely distributed in the body in the connective tissue, eye, synovial fluid of the joints, skin, and a large percentage is distributed in heart valves and nervous tissue. Also hyaluronic acid plays an important role in intercellular communication and signaling.
It is important to emphasize that the synthesis of endogenous hyaluronic acid decreases between the age of 25 and 30 years old. Its production starts to decline, and decreased synthesis may be due to some diseases. This kind of development can be stimulated with reduced ability of the body to cope with free oxygen radicals that contribute to tissue and genes damage in the body, as well as many other factors (pollutants in air, food, plastic containers (BPA), detergents, fabric softeners, dryer, pesticides, smoking, overuse of alcohol, stress ...).
Hyaluronic acid –Biocompatibility
The presence of impurities, particularly those of animal origin, may affect the biocompatibility, which can be, for example, manifested as stormy reactions in the human body. Purity of the HA preparations is therefore of crucial importance for safe use in humans¹!
Varying of molecular weight is also observed in the tissues, but there are differences between healthy and diseased tissue. The molecular size of the HA is often decreased in the synovial fluid of patients with disorders of the joints. In healthy tissue, the molecular weight of the HA is usually in the order of 5 to 10 million Da. In tissues, particularly those which are affected by the disease, the molecular weight can be reduced below 1 M Da¹.